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addgene plasmid  (Addgene inc)


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    Addgene inc addgene plasmid
    Addgene Plasmid, supplied by Addgene inc, used in various techniques. Bioz Stars score: 91/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/addgene plasmid/product/Addgene inc
    Average 91 stars, based on 4 article reviews
    addgene plasmid - by Bioz Stars, 2026-06
    91/100 stars

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    FIGURE 1 Several solid malignancies display elevated mRNA expression of ATF6 target genes. A, Expression sum of 13 known ATF6 target genes

    Journal: Cancer research communications

    Article Title: ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

    doi: 10.1158/2767-9764.CRC-24-0268

    Figure Lengend Snippet: FIGURE 1 Several solid malignancies display elevated mRNA expression of ATF6 target genes. A, Expression sum of 13 known ATF6 target genes

    Article Snippet: Colo201 ATF6 knockout (KO) cells were generated from parental Colo201 using CRISPR technology by cotransfecting a Cas9-containing plasmid, pRK-TK-Neo-Cas9, with a ATF6 (ATF6) targeting guide RNA (50-G TTG-CCAATGGCATAAGCGT-30) cloned into a pLKO vector (RRID: Addgene_139470).

    Techniques: Expressing

    FIGURE 2 Disruption of ATF6 attenuates growth of multiple colorectal cancer cell lines in vitro and in vivo. A, Viability of Colo201 cells expressing

    Journal: Cancer research communications

    Article Title: ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

    doi: 10.1158/2767-9764.CRC-24-0268

    Figure Lengend Snippet: FIGURE 2 Disruption of ATF6 attenuates growth of multiple colorectal cancer cell lines in vitro and in vivo. A, Viability of Colo201 cells expressing

    Article Snippet: Colo201 ATF6 knockout (KO) cells were generated from parental Colo201 using CRISPR technology by cotransfecting a Cas9-containing plasmid, pRK-TK-Neo-Cas9, with a ATF6 (ATF6) targeting guide RNA (50-G TTG-CCAATGGCATAAGCGT-30) cloned into a pLKO vector (RRID: Addgene_139470).

    Techniques: Disruption, In Vitro, In Vivo, Expressing

    FIGURE 3 ATF6 silencing attenuates cell-cycle progression and downregulates cell-cycle drivers. A, Colo201 and CCK81 cells expressing inducible shATF6

    Journal: Cancer research communications

    Article Title: ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

    doi: 10.1158/2767-9764.CRC-24-0268

    Figure Lengend Snippet: FIGURE 3 ATF6 silencing attenuates cell-cycle progression and downregulates cell-cycle drivers. A, Colo201 and CCK81 cells expressing inducible shATF6

    Article Snippet: Colo201 ATF6 knockout (KO) cells were generated from parental Colo201 using CRISPR technology by cotransfecting a Cas9-containing plasmid, pRK-TK-Neo-Cas9, with a ATF6 (ATF6) targeting guide RNA (50-G TTG-CCAATGGCATAAGCGT-30) cloned into a pLKO vector (RRID: Addgene_139470).

    Techniques: Expressing

    FIGURE 4 ATF6 disruption perturbs Myc and Wnt signaling and decreases colorectal cancer cell seeding capacity. A, Effect of ATF6 knockdown on Wnt

    Journal: Cancer research communications

    Article Title: ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

    doi: 10.1158/2767-9764.CRC-24-0268

    Figure Lengend Snippet: FIGURE 4 ATF6 disruption perturbs Myc and Wnt signaling and decreases colorectal cancer cell seeding capacity. A, Effect of ATF6 knockdown on Wnt

    Article Snippet: Colo201 ATF6 knockout (KO) cells were generated from parental Colo201 using CRISPR technology by cotransfecting a Cas9-containing plasmid, pRK-TK-Neo-Cas9, with a ATF6 (ATF6) targeting guide RNA (50-G TTG-CCAATGGCATAAGCGT-30) cloned into a pLKO vector (RRID: Addgene_139470).

    Techniques: Disruption, Knockdown

    FIGURE 5 β-catenin knockdown phenocopies ATF6 silencing. A, Validation of knockdown in CCK81 cells. CCK81 shATF6 cells and CCK81

    Journal: Cancer research communications

    Article Title: ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

    doi: 10.1158/2767-9764.CRC-24-0268

    Figure Lengend Snippet: FIGURE 5 β-catenin knockdown phenocopies ATF6 silencing. A, Validation of knockdown in CCK81 cells. CCK81 shATF6 cells and CCK81

    Article Snippet: Colo201 ATF6 knockout (KO) cells were generated from parental Colo201 using CRISPR technology by cotransfecting a Cas9-containing plasmid, pRK-TK-Neo-Cas9, with a ATF6 (ATF6) targeting guide RNA (50-G TTG-CCAATGGCATAAGCGT-30) cloned into a pLKO vector (RRID: Addgene_139470).

    Techniques: Knockdown, Biomarker Discovery

    FIGURE 6 Selective ATF6 inhibition attenuates colorectal cancer organoid growth while inhibiting Wnt-pathway activity. A, Viability of normal

    Journal: Cancer research communications

    Article Title: ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

    doi: 10.1158/2767-9764.CRC-24-0268

    Figure Lengend Snippet: FIGURE 6 Selective ATF6 inhibition attenuates colorectal cancer organoid growth while inhibiting Wnt-pathway activity. A, Viability of normal

    Article Snippet: Colo201 ATF6 knockout (KO) cells were generated from parental Colo201 using CRISPR technology by cotransfecting a Cas9-containing plasmid, pRK-TK-Neo-Cas9, with a ATF6 (ATF6) targeting guide RNA (50-G TTG-CCAATGGCATAAGCGT-30) cloned into a pLKO vector (RRID: Addgene_139470).

    Techniques: Inhibition, Activity Assay

    FIGURE 7 ATF6 inhibition in PDM-272 organoids attenuates cell-cycle progression and promotes multilineage intestinal differentiation. A, UMAPs

    Journal: Cancer research communications

    Article Title: ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

    doi: 10.1158/2767-9764.CRC-24-0268

    Figure Lengend Snippet: FIGURE 7 ATF6 inhibition in PDM-272 organoids attenuates cell-cycle progression and promotes multilineage intestinal differentiation. A, UMAPs

    Article Snippet: Colo201 ATF6 knockout (KO) cells were generated from parental Colo201 using CRISPR technology by cotransfecting a Cas9-containing plasmid, pRK-TK-Neo-Cas9, with a ATF6 (ATF6) targeting guide RNA (50-G TTG-CCAATGGCATAAGCGT-30) cloned into a pLKO vector (RRID: Addgene_139470).

    Techniques: Inhibition

    FIGURE 8 Wnt surrogate restores Wnt pathway activity and growth of PDM-272 organoids in context of ATF6 inhibition. A, mRNA gene

    Journal: Cancer research communications

    Article Title: ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

    doi: 10.1158/2767-9764.CRC-24-0268

    Figure Lengend Snippet: FIGURE 8 Wnt surrogate restores Wnt pathway activity and growth of PDM-272 organoids in context of ATF6 inhibition. A, mRNA gene

    Article Snippet: Colo201 ATF6 knockout (KO) cells were generated from parental Colo201 using CRISPR technology by cotransfecting a Cas9-containing plasmid, pRK-TK-Neo-Cas9, with a ATF6 (ATF6) targeting guide RNA (50-G TTG-CCAATGGCATAAGCGT-30) cloned into a pLKO vector (RRID: Addgene_139470).

    Techniques: Activity Assay, Inhibition

    KEY RESOURCES TABLE

    Journal: Cell reports

    Article Title: CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance

    doi: 10.1016/j.celrep.2023.113130

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: pEGFP-ATF6-(S1P-) , Chen et al. , Addgene (#32956).

    Techniques: Recombinant, Transfection, Protease Inhibitor, CyQUANT Assay, Proliferation Assay, Expressing, Mass Spectrometry, Software